Melanotan II Overview
Mechanism of Action
Melanotan II is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH) that binds to melanocortin receptors (MC1R through MC5R). MC1R activation stimulates melanogenesis (melanin production) in skin cells, producing a tan without UV exposure. MC3R/MC4R activation mediates appetite suppression and sexual arousal effects.
~1 hour
Timing
Evening (nausea is less noticeable during sleep)
Injection Site
Subcutaneous, abdomen
Food
Light stomach preferred; nausea more likely on full stomach
Common Stacks
- Standalone use most common
Melanotan II Dosing Protocol
Loading Phase
2–3 weeks250–500 mcg daily
Start at 250 mcg to assess tolerance. Gradually increase.
Maintenance
As desired500–1000 mcg 1–2x/week
Maintain achieved pigmentation with periodic dosing.
Melanotan II Expected Timeline
Week 1
Facial flushing; possible nausea
Week 2–3
Visible skin darkening begins
Week 4–6
Full tan effect; maintenance dosing begins
Melanotan II Side Effects
Nausea (common at initiation, decreases with use)
Facial flushing
Appetite suppression
Mole darkening (monitor existing moles)
Spontaneous erections
Melanotan II Research Studies
Superpotent melanotropin 4-10 derivative: mechanism of action
Hruby VJ, Lu D, Sharma SD, et al. — Ann N Y Acad Sci (1999)
Described the development and mechanism of Melanotan II as a superpotent melanocortin receptor agonist, establishing its pharmacological profile across multiple receptor subtypes.
PubMed: 10681895Melanotan II FAQ
Do I still need sun exposure?
Melanotan II stimulates melanin production, but some UV exposure (even brief) helps activate and distribute the melanin for a more even tan. Many users combine minimal sun exposure with MT2 for best results.
Why do moles darken?
Melanocytes in moles are especially responsive to melanocortin stimulation. Mole darkening is expected but should be monitored. Report any asymmetric changes, border irregularity, or rapid growth to a dermatologist.