Hexarelin Overview
Mechanism of Action
Hexarelin is a synthetic hexapeptide GH secretagogue activating the ghrelin receptor (GHS-R1a) with high potency. One of the strongest GHRPs. Also elevates cortisol and prolactin. Has unique direct cardioprotective effects through CD36 receptor activation, independent of GH release.
~70 minutes
Timing
Morning fasted and/or before bed
Injection Site
Subcutaneous
Food
Fasting required for GH response
Common Stacks
- CJC-1295 (no DAC) — GHRH + GHRP synergy
- Cycle 4–8 weeks on / 4 weeks off
Hexarelin Dosing Protocol
Standard Protocol
8–12 weeks100–200 mcg SQ 1–2x daily
On empty stomach. Cycle off periodically to prevent desensitization.
Cardioprotective
4–8 weeks100 mcg SQ daily
Lower dose for cardiac benefits.
Hexarelin Expected Timeline
Week 1–2
Significant GH elevation; improved sleep
Week 3–4
Enhanced recovery
Week 6–8
Body composition changes; cardioprotective effects
Hexarelin Side Effects
Cortisol/prolactin elevation
Water retention
Hunger
Receptor desensitization with continuous use
Hexarelin Research Studies
Hexarelin is a cardioprotective peptide
Bisi G, et al. — Eur J Pharmacol (1999)
Demonstrated hexarelin's unique cardioprotective properties through CD36 receptor activation, providing cardiac benefits beyond GH release.
PubMed: 10344621Hexarelin FAQ
Why does hexarelin cause desensitization?
Continuous ghrelin receptor stimulation leads to downregulation after 4–8 weeks. Cycling prevents this.
Hexarelin vs Ipamorelin?
Hexarelin is stronger but with more side effects and desensitization risk. Ipamorelin is cleaner and more sustainable.