Retatrutide Overview
Mechanism of Action
Retatrutide is a triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously, producing robust effects on weight loss, blood sugar control, and energy expenditure.
Half-Life
~5-6 days
Timing
Same day each week
Alternatives in this class
Same mechanism as Retatrutide — use as an alternative, not combined together.
- Semaglutide
- Tirzepatide
Retatrutide Dosing Protocol
Titration
0.5 mg weekly, increasing monthly
Maintenance
4-12 mg weekly
Retatrutide Expected Timeline
No timeline data available.
Retatrutide Side Effects
Nausea
Diarrhea
Decreased appetite
Injection site reactions
Retatrutide Research Studies
No studies referenced.
Retatrutide FAQ
How is Retatrutide different from Semaglutide?
Retatrutide targets three receptors (GIP/GLP-1/glucagon) vs. Semaglutide's single GLP-1 target.