Semaglutide Overview
Mechanism of Action
Semaglutide is a GLP-1 receptor agonist that enhances insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite through central and peripheral mechanisms.
Half-Life
~7 days
Timing
Same day each week
Alternatives in this class
Same mechanism as Semaglutide — use as an alternative, not combined together.
- Tirzepatide
- Retatrutide
Common Stacks
- B12
Semaglutide Dosing Protocol
Titration
0.25 mg/week for 4 weeks, then increase
Maintenance
1-2.4 mg/week
Semaglutide Expected Timeline
No timeline data available.
Semaglutide Side Effects
Nausea
Vomiting
Diarrhea
Constipation
Decreased appetite
Semaglutide Research Studies
No studies referenced.
Semaglutide FAQ
How long does it take for Semaglutide to work?
Most people notice appetite reduction within the first 1-2 weeks, with significant weight loss over 3-6 months.