Glutathione Overview
Mechanism of Action
Glutathione (GSH) is a tripeptide (glutamate-cysteine-glycine) serving as the body’s primary endogenous antioxidant and detoxification agent. It neutralizes reactive oxygen species, regenerates vitamins C and E, conjugates toxins for hepatic excretion, and modulates immune cell function. Levels decline significantly with age and toxic exposure.
~2–3 hours (injectable); rapidly distributed to tissues
Timing
Morning preferred
Injection Site
Subcutaneous or intravenous
Food
No restrictions; vitamin C may enhance effects
Common Stacks
- NAD+ — Cellular energy + antioxidant synergy
- Vitamin B12 — Methylation support
Glutathione Dosing Protocol
Standard Protocol
Ongoing200–600 mg SQ 1–3x weekly
Dose depends on vial size.
Detox/Immune Support
4–8 weeks600–1500 mg weekly
Higher doses for acute detoxification.
Glutathione Expected Timeline
Week 1–2
Improved energy; reduced oxidative stress
Week 3–4
Enhanced detoxification; brighter skin
Month 1–3
Sustained antioxidant protection
Glutathione Side Effects
Injection site discomfort
Temporary skin lightening (high doses)
Very safe at therapeutic doses
Glutathione Research Studies
Glutathione: Overview of its protective roles, measurement, and biosynthesis
Forman HJ, Zhang H, Rinna A — Mol Aspects Med (2009)
Comprehensive review establishing glutathione as the body’s ‘master antioxidant’ for antioxidant defense, detoxification, and immune function.
PubMed: 18926849Glutathione FAQ
Why inject glutathione instead of oral?
Oral glutathione has poor bioavailability — largely broken down in the GI tract. Injectable delivery provides direct bloodstream access for immediate tissue distribution.
Can glutathione lighten skin?
At high doses, glutathione can redirect melanin synthesis toward lighter pheomelanin. This effect is dose-dependent and reversible.