HMG Overview
Mechanism of Action
Human Menopausal Gonadotropin contains both FSH and LH activity. FSH stimulates ovarian follicle development (women) and spermatogenesis (men). LH stimulates testosterone production (men) and ovulation (women). Provides comprehensive gonadotropin replacement.
FSH: ~24–48 hr; LH: ~20 hr
Timing
Per prescriber protocol
Injection Site
Subcutaneous or intramuscular
Food
No restrictions
Alternatives in this class
Same mechanism as HMG — use as an alternative, not combined together.
- hCG — Combined gonadotropin support
Common Stacks
- Clomiphene — Fertility support
HMG Dosing Protocol
Male Fertility
3–6 months75 IU SQ/IM 2–3x weekly
Often combined with hCG.
Female Fertility
Per cyclePer reproductive endocrinologist
Precise dosing per follicular monitoring.
HMG Expected Timeline
Week 1–2
Gonadotropin stimulation begins
Month 1–3
Improved hormone levels
Month 3–6
Spermatogenesis improvement (men)
HMG Side Effects
Injection site pain
Ovarian hyperstimulation (women)
Gynecomastia (men)
Headache
HMG Research Studies
HMG versus recombinant FSH for ovarian stimulation
Coomarasamy A, et al. — Hum Reprod Update (2008)
Meta-analysis showing HMG associated with higher live birth rates than recombinant FSH, supporting combined FSH+LH activity.
PubMed: 18539639HMG FAQ
Is HMG different from hCG?
Yes. HMG provides FSH + LH. hCG primarily mimics LH only. They’re often combined for complementary gonadotropin stimulation.
Can HMG improve sperm count?
Yes. FSH component stimulates Sertoli cells supporting spermatogenesis. Combined with hCG for comprehensive fertility support.